Jessica Makinson is a graduate of Arizona State University, (with a B.A. in Theater), where she performed sketch and improvisation work, and helped build A.S.U.'s Farce Side Comedy Hour and Barren Mind into on-campus hits. After graduating, she moved to Los Angeles, where she studied at Improv Olympic, going on to perform in groups like Brand X, King Ten, and Squadron.
A "go-to girl" for Comedy Central producers Trey Parker and Matt Stone, Makinson guest-starred on their political sitcom, That's My Bush, and has contributed voices to their long-running animated series, South Park. She has also contributed sketches and characters to ABC's Jimmy Kimmel Live, CBS's Late Late Show with Craig Ferguson, and Showtime's The Underground.
In 2003, she starred in a season of Comedy Central's improv/hidden camera series, Trigger Happy TV, before landing the role of Eleanor on Spike TV's 2004 reality show parody, Joe Schmo 2. The following year, she starred in two pilots - The Hollywood Show for Comedy Central and The Sportsmen's News for the Outdoor Channel.
Makinson was one of the stars of the Comedy Central series, Halfway Home, in the role of Carly Barzak. She was proud to play the first female comedy drug mule on television.